The Indian Institute of Technology Jodhpur and Indian Association for the Cultivation of Science (IACS), Kolkata, have made a breakthrough in both sustainable chemistry and cancer drug discovery. They've "developed a metal-free, efficient method to create a new class of potent anti-cancer molecules. There has been a long standing problem of installing a sulfur-containing group into a chemical structure known as aniline derivative.
"Aniline is an aromatic organic compound with the formula C₆H₅NH₂ with a ring-like structure. The resulting compounds, called S-aryl dithiocarbamates, have demonstrated valuable antiproliferative activity against breast cancer cells at a nanomolar level by interfering with the cell's internal scaffolding."
Green chemist praise the "metal-free and additive-free, one-pot, multicomponent reaction that operates under mild, room-temperature conditions".
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