Calicheamicin is a highly potent enediyne antitumor antibiotic from Micromonospora echinospora, which cleaves DNA via sequence-specific double-strand breaks. It is employed as the cytotoxic payload in antibody–drug conjugates (ADCs) such as gemtuzumab ozogamicin and inotuzumab ozogamicin for targeted leukemia treatment.
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Human health and environmental benefits
Serves as a precise, potent payload in ADCs to maximize cancer cell targeting and minimize damage to healthy tissues, thereby improving treatment safety and reducing environmental exposure to cytotoxic agents.
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United States