Many organizations have worked to define and describe sustainable chemistry or have developed principles for safety and sustainability for chemistry applications, including environmental justice principles centered around chemicals management. Through research, analysis, and extensive discourse, the Expert Committee on Sustainable Chemistry (ECOSChem)—representing a broad set of constituencies—has built upon these foundations with an aim to develop a clear and actionable definition and set of criteria that may be adopted and adapted to different constituencies and decision contexts, including in policy, education, corporate, and investment decision making. It is also intended to guide chemical, material, process, and product design and implementation in different settings.