Wastewater-based epidemiology (WBE) and other environmental epidemiology methods are valuable public health tools aimed to yield relevant epidemiological information for a community. This information includes lifestyle and dietary behaviors, general population health, and exposure to contaminants. There has been a significant increase in WBE’s popularity due to the global COVID-19 pandemic. From January 2021 to May 2023, I analyzed SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) RNA in wastewater from dormitories on George Mason University’s Fairfax campus. The collected wastewater data was then statistically analyzed establishing a correlation with the number of positive COVID-19 cases on campus identified through individual saliva testing. Additionally, degradation experiments were carried out to quantify the stability of molecular markers in the presence of various macromolecules. This research seeks to close the gap in knowledge on the stability of free RNA in aqueous and complex media. To expand on environmental epidemiology’s capabilities, this research aims to analyze and quantify environmental contaminants in stormwater. This methodology aims to quantify patterns of contaminant exposure across various communities and establish correlations regarding socioeconomic disparities. Despite its promises, environmental epidemiology is still in infancy and many challenges and difficulties associated with its technology must be overcome.