Thioamides are versatile tools that are used both as synthetic precursors to complex heterocyclic compounds, and also commercially due to their range of bioactive properties. These include antimicrobial, antioxidant and most notably antithyroid activities among others. Traditional synthesis of thioamides typically employ the use of smelly, multi-step protocols with poor atom economy and cumbersome clean-up. Furthermore, these protocols utilize harsh reaction conditions, long reaction times, limited scope and poor waste management. Multicomponent reactions (MCRs) which convert three or more reactants to a single product, in one step, are therefore efficient tools for the synthetic chemist, to access diverse products with good waste management and greener materials. Elemental sulfur is a benign and abundant resource, that has been suitably applied to MCRs for an array of sulfur-insertion products. Sulfur-mediated MCRs may access thioamides in one-pot with good yields, a wider substrate scope, reduction in the length of the reaction, lower temperatures and waste minimization. These reactions are thus advantageous, sustainable alternatives to traditional synthetic methods of thioamides.