his research focuses on the design and optimization of supramolecular deep eutectic solvents (SUPRADES) for the extraction of bioactive compounds and the exploration of potential applications. SUPRADES represent a novel subclass of deep eutectic solvents (DES) that could have a significant impact on green chemistry due to their enhanced inclusion properties, offering a promising alternative to conventional solvents. They may provide higher selectivity and efficiency in extracting different families of compounds. Existing literature indicates that the most commonly used macrocycles in SUPRADES synthesis are cyclodextrins (CD) because their structure enables selective interaction with numerous compounds. CDs leverage their ability to form inclusion complexes with various molecules and small organic and inorganic polymers, referred to as CycloDES. These solvents, which are entirely eco-friendly, non-toxic, and biodegradable, demonstrate greater efficiency compared to DES in the extraction of bioactive compounds.
The research will explore the use of CycloDES in efficient and sustainable extraction methods for obtaining compounds with antimicrobial properties and their potential for other biotechnological applications (e.g., remediation, sorbents, adhesive materials, drug delivery vehicles). The goal is to design SUPRADES by selecting suitable forming compounds, prioritizing cyclodextrins, and optimizing the variables involved in both the synthesis and extraction processes to enhance the capacity to extract bioactive compounds (anthocyanins and carotenoids) from grape and tomato waste.