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Enzymatic Synthesis

Regioselective Biocatalytic De-O-Acetylation of Tetraacetyl Thioglycosides

Carbohydrate mimetics play vital roles in various cell-mediated processes due to their structural resemblance to natural sugars, yet they exhibit distinct properties. Thioglycosides, in which an exocyclic oxygen atom is replaced by sulfur, are recognized as key building blocks in the preparation of glycans and the development of novel monosaccharides. These compounds serve as valuable intermediates in carbohydrate chemistry, being widely utilized in sequential glycosylation strategies for oligosaccharide synthesis.

Sustainable Dyes and Pigments Through Fermentation

PILI is a biotech company that produces dyes and pigments using microorganisms for applications in textiles, inks, polymers, paints, and coatings. The technology uses microbial enzymes, which are re-engineered to produce brilliant and effective dyes from renewable resources. Enzymatic synthesis allows microbes to create materials sustainably by saving energy and reducing waste without significant inputs of toxic reagents. Once enzymatic cascades are designed, large-scale production begins without toxic inputs or harmful byproducts.

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