metrics

The rapid communication explores how to collect mass balance data (reagent amounts, products, waste) to generate metrics to evaluate material circularity and efficiency for chemical transformations. It explores the relationships between three simple metrics (process mass intensity, e-factor, and recycled content) to explore transformations holistically. There is a short case study exploring how these are applied to evaluate and compare different processes. 

The Acid-Base Selection Tool developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable aims to enable scientists across industry and academia to choose more sustainable acids and bases. The Acid-Base Tool contains over 200 acids and bases which the user can filter by parameters including pKa (in water or acetonitrile), functional groups, melting point, and boiling point. 

This tool is a slightly different approach to accounting for Process Mass Intensity (PMI) by focusing on waste. A joint effort by the IQ Consortium, ACS GCI Pharmaceutical Roundtable, and academic leaders, this Green Chemistry Innovation Scorecard web calculator illustrates how green chemistry and engineering innovation can reduce waste mass during bulk active pharmaceutical manufacture. The calculator uses a statistical analysis of 64 bulk active pharmaceutical manufacturing processes encompassing 703 steps across 12 companies to provide a relative process greenness score.