Over the last decade, improvements in high-pressure liquid chromatography (from HPLC to UHPLC) and supercritical fluid chromatography (from SFC to UHP-SFC) have led to faster and more efficient separations. However, many of these improvements have yet to be implemented. To encourage analysts to develop greener methods, the Analytical Method Greeness Score (AMGS) calculator provides a straightforward metric to enable the comparison of separation methods used in drug development. The AMGS metric includes the health, safety, and environmental impact of the solvent, cumulative energy demand, instrument energy usage, and method solvent waste to benchmark and compare methods.
This tool was developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable's analytical chemistry focus team.