In this research, we synthesized DNA@AuNR coronazymes with gold nanorods (AuNRs) coronated with DNA for superior catalytic efficiency. Furthermore, the localized surface plasmon resonance (LSPR) excitation of AuNRs facilitates plasmon-responsive photocatalysis. The charge transfer between the AuNR and DNA, known as plasmon-induced chemical interfacial damping results in tunable catalytic enhancement. The presence of DNA causes significant CID effect which hinders the charge recombination and prolongs the lifetime for efficient charge transfer which also correlates with the DNA coverage. This comprehensive study has enhanced our understanding of catalytic mechanism in a biohybrid system. The use of single-molecule analysis techniques significantly reduces the amount of catalyst for the study making the study more sustainable and less wasteful. In this study, we harnessed plasmon induced catalytic enhancement for tunable photocatalysis. The use of light as an energy source for enhancing catalysis presents great implications in energy efficiency and sustainability.