The ACS Green Chemistry Institute® Pharmaceutical Roundtable (GCIPR) was developed in 2005 to encourage the integration of green chemistry and green engineering into the pharmaceutical industry. One of the strategic priorities of the Roundtable is to inform and influence the research agenda and an early step was the publication of a paper on key green chemistry research areas (KRA) from a pharmaceutical manufacturers’ perspective. The publication was followed up with the ongoing GCIPR Research Grant Programme. For the 10th Anniversary of GCIPR, we decided to revisit the original KRA, the organization having 15 members compared to six in 2006. The original six-member companies all participated in the exercise, although some company names have changed because of changes within the pharmaceutical industry. This paper discusses the selection and updated list of key green chemistry research areas, solvent themes and a brief commentary on the emerging area of medium molecules.