UiO-66 is a thermal and chemically stable Zr-based metal-organic framework (MOF). Its stability has enabled potential applications for this MOF, ranging from the degradation of organophosphorus nerve agents to the breakdown of pre- and poly-fluoroalkyl substances (PFAS). However, the current solvothermal synthesis of UiO-66 is inefficient and wasteful. The desire for a greener synthesis of UiO-66 has driven efforts to develop an efficient mechanochemical synthesis. This poster shows that UiO-66 can be synthesized rapidly using mechanochemistry directly from commercially available materials in one pot using modulators. Using liquid-assisted grinding (LAG) in a ball mill, UiO-66 can be created more efficiently and environmentally conscious in 30 minutes with minimal organic solvents. The characterization of this MOF was done using powder X-ray diffraction (PXRD), and further work is ongoing to understand the mechanism of this reaction.