Synthesis of simvastatin with a biocatalyst. Simvastatin is a drug used to treat high blood pressure and cholesterol. The conventional synthesis of this drug is not atom-economic (<70% original mass) and utilizes toxic feedstocks. This new process from Professor Tang and his research group at UCLA uses a biocatalyst for regioselective acylation with safer and cheaper reagents in a high-yield, single-step process.
EPA Presidential Green Chemistry Challenge: 2012 Greener Synthetic Pathways Award
Inventor/Owner/Manufacturer/Supplier
Codexis, Inc.
Inventor/Owner/Manufacturer/Supplier: Other
Codexis, Inc. Professor Yi Tang of the University of California, Los Angeles
Stage of Development
Category
Keywords
Image
