Synthesis of simvastatin with a biocatalyst. Simvastatin is a drug used to treat high blood pressure and cholestrol. The conventional synthesis of this drug is not atom-economic (<70% original mass) and utilizes toxic feedstocks. This new process from Professor Tang and his research group uses a biocatalyst for regioselective acylation with safer and cheaper reagents in a high-yield, single-step process.
Contact/Additional InfoProfessor Yi Tang:
Tel: 310-825-0375
Email:[email protected]
Codexis:
Tel: 650-421-8100
Email: [email protected]
Websites:
https://www.codexis.com/
https://www.chemistry.ucla.edu/directory/tang-yi/
Codexis, Inc. Professor Yi Tang of the University of California, Los Angeles
Publications:
https://www.epa.gov/greenchemistry/presidential-green-chemistry-challenge-2012-greener-synthetic-pathways-award