Heterocycles

Many organic molecules are efficient light emitters used for optoelectronic devices such as OLEDs, due to their advantages over metallic counterparts, including lower toxicity, simpler disposal, and sustainability. However, the methodologies commonly used in organic synthesis to obtain these molecules often rely on harsh conditions and generate large amounts of waste, making them both ineffective and inefficient. This work aligns with some of the principles of green chemistry across different stages.

In recent decades there has been uprising interest in the medicinal properties of organoselenides. These ubiquitous structural have their wide applications in material sciences, in catalysis and modern organic transformations. Research studies have led to important discoveries regarding selective C–Se bond formation and in this context a notable approach is direct selenylation. In this regard, nitrogen- or oxygen-containing arenes with organoselenides have appeared as a very important class of molecules, with diverse applications in the biological sciences.

Throughout history, natural products have consistently proven to be invaluable sources of solutions for humanity, particularly regarding the development of treatments for diseases. If only small molecules are taken into consideration, almost half of the approved anti-cancer drugs since mid-last century are either natural products or compounds related to them in some way. Among the natural products that have gained increasing interest in recent decades are cannabinoids and related meroterpenoids. 

Sulfonamides represent an important family of compounds with diverse biological activities, especially recognized as antibiotics. 1,2,4-Benzothiadicines-1,1-dioxide belong to a family of cyclic sulfonamides with significant pharmacological applications, such as antimicrobial, antiviral and antidiabetic. In addition, they are used clinically as diuretics and antihypertensives.