Sulfonamides represent an important family of compounds with diverse biological activities, especially recognized as antibiotics. 1,2,4-Benzothiadicines-1,1-dioxide belong to a family of cyclic sulfonamides with significant pharmacological applications, such as antimicrobial, antiviral and antidiabetic. In addition, they are used clinically as diuretics and antihypertensives.
Scientific research has focused mainly on substituted 1,2,4-benzothiadicines, but not so much on fused systems such as azolo[1,2,4]benzothiadiazine. However, triazolo[1,2,4]benzothiadiazine derivatives have been shown to have potent antiproliferative and antibacterial activities, which has sparked great scientific interest in the development of new synthetic routes for cyclic sulfonamides. Existing synthesis routes typically involve the use of metals, high temperatures and long reaction times, making them expensive and environmentally damaging. Therefore, there is interest in developing more innovative and sustainable synthetic strategies.