click chemistry

Protease-activated receptor 2 (PAR2) is a G-protein-coupled receptor critical in regulating inflammation, pain, and physiological functions such as wound healing and epithelial barrier integrity. Chronic PAR2 activation contributes to numerous inflammatory and immune diseases, including inflammatory bowel disease (IBD), asthma, and arthritis, and plays a role in tumor progression by promoting proliferation, angiogenesis, and metastasis.

The development of sustainable and environmentally friendly materials is a key component of the green chemistry concept. In this context, cellulose tosylate (MCC-Tos) serves as a versatile precursor for the functionalization of cellulose. By substituting tosyl groups with alkyne groups, the potential of cellulose is enhanced, making it compatible with click chemistry reactions such as thiol-yne and copper-catalyzed alkyne-azide cycloaddition (CuAAC), which promotes greener processes.