Chemical Safety

A framework for chemical hazard assessments under Safe and Sustainable by Design using multiple in silico tools

The hazard identification of chemicals is a key step of the “Safe and Sustainable by Design” (SSbD) framework introduced by the European Commission, aiming to eliminate hazardous substances early in innovation. In this context, in silico methods such as (Quantitative) Structure–Activity Relationship ((Q)SAR) models offer rapid, cost-effective, and animalfree alternatives for early-stage hazard screening. The Partnership for the Assessment of Risks from Chemicals (PARC) is developing a toolbox to facilitate SSbD assessments containing numerous (Q)SAR models.

Report on the State of the Science to Address Endocrine Disrupters Under the Globally Harmonised System of Classification and Labelling

A variety of chemicals may interfere with the endocrine systems of humans and wildlife. To protect humans and the environment from potential adverse effects, there is interest in identifying such chemicals and classifying the hazard. To evaluate available methods to identify endocrine disrupters under the United Nations Globally Harmonised System for Classification and Labelling of Chemicals (GHS), the OECD convened an expert group to provide input.

Guidance Document on the Generation, Reporting and Use of Research Data for Regulatory Assessments

This Guidance Document aims to enhance utility and regulatory uptake of research data. The document focuses on hazard, exposure and risk assessment data generated outside of regulatory testing frameworks, promoting harmonised approaches for using scientifically robust, reliable and relevant information for decision-making across jurisdictions and policy areas. The document is structured around the lifecycle of research data, from generation and reporting to identification, evaluation and integration into regulatory assessments.

Current and emerging issues in chemical food safety

Abstract: Food safety is increasingly influenced by global challenges, such as climate change, environmental pollution, the shift toward plant-based diets, and new technological developments. This review addresses key issues currently shaping chemical food safety, focusing on natural toxins in plant-based foods, the effects of climate change on food safety, and the role of endogenous compound formation in exposure assessments.