Thailanstatin A
Thailanstatin A is a potent natural product isolated from Burkholderia thailandensis MSMB43. It functions as an ultra-potent inhibitor of eukaryotic RNA splicing by binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome. This mechanism results in low-nanomolar to sub-nanomolar IC50 values across various human cancer cell lines, including DU-145, NCI-H232A, MDA-MB-231, and SKOV-3.