PMI

The Biopharma Process Mass Intensity (PMI) metric provides a standard method for collecting mass data on the amount of water, raw material, and consumables used to produce 1 kg of biologic drug substance (API). This metric uses common parameters to define biologics manufacturing, which allows for industry-wide bench-marking, increased transparency during process development, and a method to objectively compare processes.

Decreasing the overall quantity of materials used to manufacture a final product is a significant challenge for pharmaceutical companies. Because of the large amount of solvent used in typical manufacturing processes, decreasing materials used saves companies money (less purchased and less energy used in workup and isolation). The Process Mass Intensity (PMI) metric was developed as a way to benchmark and quantify improvements towards greener manufacturing processes.