toxicology

Alternatives Assessment Criteria for Hazard Evaluation

Design for the Environment Program Alternatives Assessment Criteria for Hazard Evaluation
Tool Owner
US Environmental Protection Agency (US EPA)

The Design for the Environment (DfE) Program at the U.S. Environmental Protection Agency developed the Alternatives Assessment Criteria for Hazard Evaluation as a transparent tool for evaluating and differentiating among chemicals based on their human health and environmental hazards. The Criteria are applied in all of DfE Alternatives Assessments and can be used by other organizations.

To ensure that the Criteria remain relevant and useful for distinguishing among chemicals, DfE may update criteria based on experience conducting alternatives assessments and on stakeholder input.

Toxicity 101 for Early-Stage Investors

The document explains that many everyday products contain hazardous chemicals that create risks for health, the environment, and businesses, emphasizing that uncovering the risks and liabilities of these materials should be a standard part of due diligence, and it provides suggestions on how to incorporate safer chemistry into that process while encouraging a shift toward safer alternatives in response to growing regulations and consumer demand.

GreenScreen® for Safer Chemicals® Methodology

GreenScreen logo
Tool Owner
Clean Production Action

GreenScreen for Safer Chemicals® (“GreenScreen”) is a chemical hazard assessment methodology. 

The guidance provided in this publication clearly outlines every step for performing GreenScreen assessments, including how to assess and classify hazards, derive GreenScreen Benchmark™ scores and GreenScreen List Translator™ scores, and make informed decisions.

Guidance on Key Considerations for the Identification and Selection of Safer Chemical Alternatives

This guidance was developed with the aim to advance broader agreement on a general approach and criteria for the selection of safer alternatives, with a focus on chemical substitution. It is intended to advance a consistent understanding of the minimum requirements needed to determine whether a chemical alternative is safer than the priority chemical, product, or technology for substitution, independent of the entity performing the assessment or the alternatives assessment framework being used. 

Webinar- INVITES-IN, a new tool for assessing the internal validity of in vitro studies

This ECHA science seminar features an interdisciplinary project team, Dr Angela Bearth, Dr Gro Haarklou Mathisen and Dr Paul Whaley, all leading experts in their respective fields of applied social psychology, chemical risk assessment, and systematic review and evidence appraisal. They present a tool, INVITES-IN, for assessing the internal validity (reliability) of in vitro studies, with a view to supporting the evaluation and use of such studies in regulatory hazard and risk assessment.

Safe-and-sustainable-by-design approach to polyesters from non-oestrogenic bisphenols

Most contemporary chemical processes rely on non-renewable resources and reagents associated with negative impact on environment and human health. As a result, the safe-and-sustainable-by-design (SSbD) framework is launched to guide the innovation towards safe and sustainable materials and chemical products. Bisphenol A (BPA) is a widely used chemical in the production of plastics but known to activate oestrogen receptors and linked by numerous studies to adverse effects on both human health and the environment.

OPERA: Open (Quantitative) Structure-activity/property Relationship App

Text spelling OPERA, with the "O" as a hexagon with a swirl inside of it.
Tool Owner
US Environmental Protection Agency (US EPA)

The Open (Quantitative) Structure-activity/property Relationship App (OPERA) is a free and open-source/open-data suite of QSAR models providing predictions for toxicity endpoints and physicochemical, environmental fate, and ADME properties. OPERA was created in alignment with rigorous OECD standards to provide a regulatory-oriented alternative to experimental measurements. All OPERA models were built on curated data and QSAR-ready chemical structures standardized using an open-source workflow implemented in the application. Models are explained in the 2018 publication by Mansouri et.

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