The DOZN™ tool is a quantitative, industry-first tool that uses the 12 principles of green chemistry for comparing the relative greenness of similar chemicals, synthetic routes, and chemical processes. We distill these 12 Principles of Green Chemistry into three major categories: improving resource use, more efficient use of energy, and minimizing human and environmental hazards.
The Process Mass Intensity (PMI) Prediction Calculator was created by the ACS GCI Pharmaceutical Roundtable member companies, with leadership from Bristol-Myers Squibb, to predict a range of probable process efficiencies of proposed synthetic routes at various phases of drug development. The tool uses historical PMI data from multiple pharmaceutical companies and predictive analytics (Monte Carlo simulations) to estimate the probable PMI ranges.
The PMI-LCA Tool is a high-level estimator of Process Mass Intensity (PMI) and environmental life cycle information that can be customized to fit a wide variety of linear and convergent processes for synthesis of small molecule active pharmaceutical ingredients (APIs). An ecoinvent dataset is utilized as the source of the life cycle impact assessment (LCIA) data.
Process Mass Intensity is a common metric used in industry to measure the overall amount (or mass) of materials used to create a given amount (mass) of product. This calculator builds on the original Process Mass Intensity (PMI) calculator to accommodate convergent synthesis. Developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable, the Convergent PMI Calculator uses the same calculations but allows multiple branches for single-step or convergent synthesis.
Decreasing the overall quantity of materials used to manufacture a final product is a significant challenge for pharmaceutical companies. Because of the large amount of solvent used in typical manufacturing processes, decreasing materials used saves companies money (less purchased and less energy used in workup and isolation). The Process Mass Intensity (PMI) metric was developed as a way to benchmark and quantify improvements towards greener manufacturing processes.
Given the importance of solvents to process mass intensity, solvent selection has been an area of intense interest to ACS GCI Pharmaceutical Roundtable member companies. While there are a variety of solvent selection tools available, this is the first tool that has been developed by practicing pharmaceutical process development experts. This interactive tool enables you to select solvents based upon a variety of key solvent properties. Solvents which are close to each other in the principal components (PCA) map have similar properties, whereas distant solvents are significantly different.
The game was designed to introduce students to safer chemical design concepts that are focused on the manipulation of molecule parameters in order to minimize the undesired biological and environmental interactions of a hypothetical commercial chemical. The game scenarios model the decision making process used by professionals to design a new chemical. Critically, the computer game simulates the real-world constraints that may affect chemical product development as the student designs a novel product.
Biodegradable sorbent that captures nutrients in water. Phosphorus and nitrogen are nutrients in water that act as fertilizers for aquatic plants. Eutrophication occurs when there is an overabundance of these nutrients. Nutrient pollution occurs when eutrophication produces an excessive amount of algae. These algae disrupt ecosystems by lowering the amount of dissolved oxygen in water, reducing water quality, turning the water green, causing a foul smell, blocking sunlight, and harming animals and humans who consume it.
Large-scale anaerobic biotreatment system. Asarco's biotreatment system consists of a settling basin and two anaerobic bioreactors discharged into a rock filter polishing cell that are followed by a final aeration polishing pond. Heavy metal pollution occurs when excavated rocks or exposed underground mines get into water. The West Fork Biotreatment plant does not require conventional chemicals often associated with sludge formation nor constant human monitoring and frequent sludge disposal.
Fluorine-free and APEO-free water repellent textile finishing agents based on proprietary dendrimer technology. Highly efficient and durable performance with low application. Does not affect fabric quality and appearance. Free of fluorine and APEO.