Neglected tropical diseases, such as Chagas disease caused by Trypanosoma cruzi, remain a critical global health problem, particularly in underprivileged communities. Our research aims to develop potential therapeutic agents by synthesizing and characterizing analogues of aureothin, a polyketide with known antiparasitic activity.
Heterocyclic ring systems are essential in drug design, serving as core structures in many approved drugs. Nitrogen- and oxygen-containing heterocycles, in particular, have become increasingly significant in recent years. Despite the availability of efficient synthetic methods, there is an ongoing need for new approaches that offer higher molecular complexity, better functional group compatibility, and atom economy, using readily available starting materials under mild conditions.
Produced by the medicinal chemistry focus team of the ACS GCI Pharmaceutical Roundtable, this quick tips guide covers purification, solvent selection, reagents, energy, and resources to make medicinal chemistry more sustainable.