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Progress towards a more sustainable synthetic pathway to ibuprofen through the use of solar heating

Publication Date
Authors
Author Name
Brian M. Agee
Author Name
Gene Mullins
Author Name
Daniel J. Swartling

Ibuprofen is a nonsteroidal anti-inflammatory drug that is commonly used worldwide for pain relief and fever/inflammation reduction. It was discovered in the 1960s by Andrew Dunlop, who initially tested the drug on cures for hangovers. The drug was first made available via prescription in 1974 (United States) and soon became available as an over the counter drug purchasable at retail shops around the globe.

The synthetic procedure to synthesize ibuprofen was patented by the Boots Pure Drug Company in the 1960s. Their synthetic process involved several complicated steps that generated a considerable amount of chemical waste. Since the Boots method of synthesizing ibuprofen generated an enormous amount of waste when performed on the industry scale, alternative synthetic routes the drug have became of public interest.

Source
Sustainable Chemical Processes
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