Synthesis of sitagliptin for drug, Januvia, developed through a collaboration between Merck & Co., Inc. and Codexis, Inc. Januvia is used to treat type II diabetes. The active ingredient, sitagliptin, conventionally requires an expensive and energy-intensive crystallization and high-pressure step. These companies use transaminase enzymes to increase selectivity and efficiency and reduce overall waste.
EPA Presidential Green Chemistry Challenge: 2010 Greener Reaction Conditions Award
Inventor/Owner/Manufacturer/Supplier
Merck & Co., Inc.
Inventor/Owner/Manufacturer/Supplier: Other
This is Merck & Codexis collaboration.
Stage of Development
Category
Image
