Zenfold sustainable technologies, based in India, is integrating green chemistry principles for manufacturing complex chemical molecules for use in pharmaceuticals, nutraceuticals, electronics, and veterinary medicine and utilizing biocatalysis, solvent reduction, and zero-discharge infrastructure into their production process.
Some key market applications:
Ensitrelvir fumarate is an orally active antiviral compound that inhibits the SARS-CoV-2 3CL protease, blocking viral replication. As a small-molecule therapeutic, it is used in the development of COVID-19 treatments and related antiviral research.
Thailanstatin A is a potent natural product isolated from Burkholderia thailandensis MSMB43. It functions as an ultra-potent inhibitor of eukaryotic RNA splicing by binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome. This mechanism results in low-nanomolar to sub-nanomolar IC50 values across various human cancer cell lines, including DU-145, NCI-H232A, MDA-MB-231, and SKOV-3.
Calicheamicin is a highly potent enediyne antitumor antibiotic from Micromonospora echinospora, which cleaves DNA via sequence-specific double-strand breaks. It is employed as the cytotoxic payload in antibody–drug conjugates (ADCs) such as gemtuzumab ozogamicin and inotuzumab ozogamicin for targeted leukemia treatment.
Sulfadimethoxine sodium (Sulphadimethoxine sodium) is a sulfonamide antibiotic used to treat many infections.
Sulfadimethoxine is a sulfonamide antibiotic. Sulfadimethoxine is used to treat many infections, including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some countries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid.
Merck & Co. has developed a “continuous process” to produce KEYTRUDA® (pembrolizumab), an immunotherapy drug that increases the immune system to detect and fight tumor cells. In the new process developed by Merck, proteins are filtered away from the cells continuously rather than performing a one-time filtration step at the end of a batch.
DUDE CHEM is a German-based startup dedicated to advancing sustainable chemical production. The company aims to revolutionize the chemical-pharmaceutical industry by developing greener active pharmaceutical ingredients (API) and intermediates.
Bright Path Laboratories is a pharmaceutical company committed to changing the way American medicine is sourced and manufactured. By using a continuous flow platform and their patented Spinning-Tube-in-Tube (STT) Reactor™, Bright Path produces large quantities of medicine more quickly, cost-effectively, and with superior quality compared to competitors.
Merck Research Laboratories redesigned the manufacturing process for Zerbaxa™, a drug used to treat gram-negative bacterial infections resistant to conventional antibiotics. Ceftolozane sulfate is a key ingredient of the drug. Unfortunately, existing processes for its production require hazardous chemicals, a high process mass index, long cycle times, and low yields. Merck developed a sustainable second-generation manufacturing route.