Organic Chemistry

Research Grants for Faculty at Principally Undergraduate Institutions

In 2017, Organic Syntheses, Inc. began a program funding summer research grants for faculty at principally undergraduate institutions. Each grant award provides $8,000 to a PUI faculty member who subsequently chooses an undergraduate coworker from among the students in their department. Further information and instructions for applying for summer research grants can be found at https://www.orgsyn.org/puigrants.aspx .

Sulfur-Mediated Multicomponent Reactions in the Synthesis of Thioamides

Thioamides are versatile tools that are used both as synthetic precursors to complex heterocyclic compounds, and also commercially due to their range of bioactive properties. These include antimicrobial, antioxidant and most notably antithyroid activities among others. Traditional synthesis of thioamides typically employ the use of smelly, multi-step protocols with poor atom economy and cumbersome clean-up. Furthermore, these protocols utilize harsh reaction conditions, long reaction times, limited scope and poor waste management.

Modification of Natural Products via Chan-Lam Coupling: A Greener Approach for C-Heteroatom Bond Formation

Natural products, have long been recognized as a rich and diverse source of biologically active compounds with a wide range of therapeutic applications, and they also constitute a source of renewable and sustainable substrates for the Chan-Lam coupling. The Chan-Lam reaction is a copper-catalyzed oxidative cross-coupling that allow the formation of C-Heteroatom bonds, this coupling stands out for its alignment with green chemistry principles, enabling the efficient formation of carbon-heteroatom bonds under environmentally friendly conditions.