ACS Green Chemistry Institute Pharmaceutical Roundtable Key Research Areas Grants
Help advance key green chemistry research areas with this $80,000 grant for a one-year commitment.
2026 Key Areas:
Help advance key green chemistry research areas with this $80,000 grant for a one-year commitment.
2026 Key Areas:
This article is a book review.
The purpose of this paper is to sketch the environmental engagement among ACS chemists, in particular through the lens of membership figures, for the 1960-1990 period. I will argue that this history should not be forgotten.
Thioamides are versatile tools that are used both as synthetic precursors to complex heterocyclic compounds, and also commercially due to their range of bioactive properties. These include antimicrobial, antioxidant and most notably antithyroid activities among others. Traditional synthesis of thioamides typically employ the use of smelly, multi-step protocols with poor atom economy and cumbersome clean-up. Furthermore, these protocols utilize harsh reaction conditions, long reaction times, limited scope and poor waste management.
Natural products, have long been recognized as a rich and diverse source of biologically active compounds with a wide range of therapeutic applications, and they also constitute a source of renewable and sustainable substrates for the Chan-Lam coupling. The Chan-Lam reaction is a copper-catalyzed oxidative cross-coupling that allow the formation of C-Heteroatom bonds, this coupling stands out for its alignment with green chemistry principles, enabling the efficient formation of carbon-heteroatom bonds under environmentally friendly conditions.
Unsymmetrical ethers are generally synthesized via the Williamson ether method, but the unwanted formation of symmetrical ethers plus the basic and harsh conditions of the route pose a synthetic challenge. Other methods employed in the synthesis of unsymmetrical ether require the use of toxic mineral acids, and requires high catalyst loading which limits their large-scale application. Dehydration of alcohols in the presence of base-metal catalyst has, however, recently offered the greenest approach to synthesize unsymmetrical ethers, leaving water as by-product.