Simvastatin Manufacturing Through Biocatalysts
Synthesis of simvastatin with a biocatalyst. Simvastatin is a drug used to treat high blood pressure and cholesterol. The conventional synthesis of this drug is not atom-economic (<70% original mass) and utilizes toxic feedstocks. This new process from Professor Tang and his research group at UCLA uses a biocatalyst for regioselective acylation with safer and cheaper reagents in a high-yield, single-step process.