Sulfonamides represent an important family of compounds with diverse biological activities, especially recognized as antibiotics. 1,2,4-Benzothiadicines-1,1-dioxide belong to a family of cyclic sulfonamides with significant pharmacological applications, such as antimicrobial, antiviral and antidiabetic. In addition, they are used clinically as diuretics and antihypertensives.
Mycobacterium tuberculosis (Mtb), an opportunistic pathogen, is responsible for tuberculosis (TB), one of the deadliest infectious diseases. The mycomembrane of Mtb contributes to its resistance against many broad-spectrum antibiotics due to its lipid-rich structure, primarily composed of mycolic acids. Inhibiting the biosynthesis of mycolic acids is a promising strategy in TB drug discovery, as this pathway is enriched with essential enzymes that could serve as selective drug targets.
The development of sustainable methodologies for the synthesis of organic compounds is a fundamental challenge in modern organic chemistry. This project is focused on advancing the fields of photoredox catalysis (PRC) and synthetic photoelectrochemistry, exploring their applications in oxidative C-H substitution reactions.
Neglected tropical diseases, such as Chagas disease caused by Trypanosoma cruzi, remain a critical global health problem, particularly in underprivileged communities. Our research aims to develop potential therapeutic agents by synthesizing and characterizing analogues of aureothin, a polyketide with known antiparasitic activity.
Corrosion is a highly undesirable phenomenon in the oil and gas industry, which relies on metallic pipelines to transport acidic compounds or in corrosive environments. This issue can lead to significant economic losses due to structural damage and environmental harm associated with toxic corrosion inhibitors. In this context, green corrosion inhibitors have emerged as a promising alternative, offering high efficiency, biodegradability, and low toxicity, while being derived from natural and sustainable sources.
This study presents a methodology for bioactivity-guided fractionation of chemically modified Ambrosia tenuifolia extracts using mild derivatization conditions at room temperature. New trypanocidal compounds less toxic than the starting materials were obtained in a single reaction step. In addition, bioinformatics tools were used to identify potential biological targets for Trypanosoma cruzi, reducing the need for extensive biological testing.
Traditional methods of oxidizing alcohols often rely on toxic reagents, as well as high pressures and temperatures, which can be hazardous. In contrast, biocatalysis utilizes enzymes as natural and non-toxic catalysts, typically under milder reaction conditions. This study aims to perform oxidation reactions of primary and secondary alcohols using enzymes as catalysts.
The use of light energy, which is considered a clean and traceless reagent, for the synthesis of complex heterocyclic molecules makes organic photochemistry one of the important green chemistry tools. Photochemistry holds an important role in accessing biologically relevant molecules containing complex skeletons that are difficult to access by conventional thermal methods. Skeletons that are difficult to obtain through ground state chemistry, can be constructed using light as a reagent, producing high energy excited states required for the molecules to undergo required transformation.
Our growing population, development, and increasing energy demands will strain the environment in the coming decades, necessitating breakthroughs in sustainable energy generation and storage. State-of-the-art lithium-ion batteries face significant challenges, including limited lithium resources, safety issues, and electrochemical performance nearing theoretical limits. Novel rechargeable batteries, such as magnesium-ion batteries, present promising alternatives due to their material abundance and improved safety.
Carbohydrate mimetics play vital roles in various cell-mediated processes due to their structural resemblance to natural sugars, yet they exhibit distinct properties. Thioglycosides, in which an exocyclic oxygen atom is replaced by sulfur, are recognized as key building blocks in the preparation of glycans and the development of novel monosaccharides. These compounds serve as valuable intermediates in carbohydrate chemistry, being widely utilized in sequential glycosylation strategies for oligosaccharide synthesis.