Greener Synthesis
Synthesis of bioactive molecules from 5-hydroxymethylfurfural vía Passerini multicomponent reaction (ACS Green and Sustainable Chemistry Summer School, GSCSS - 2024)
The pharmaceutical industry is currently experiencing increasing demand for small-molecule drugs. However, a significant portion of the raw materials used in drug production are fossil-based, originating from crude oil. This reliance on non-renewable resources presents major challenges, particularly in the context of global environmental crises such as climate change, greenhouse gas emissions, and dwindling oil reserves.
Continuous Process for PD-1 Therapy – KEYTRUDA®
Merck & Co. has developed a “continuous process” to produce KEYTRUDA® (pembrolizumab), an immunotherapy drug that increases the immune system to detect and fight tumor cells. In the new process developed by Merck, proteins are filtered away from the cells continuously rather than performing a one-time filtration step at the end of a batch.
ACS GCI Pharmaceutical Roundtable Research Grants
Purpose:
To address key synthetic chemistry and process research challenges whose solutions result in more efficient pharmaceutical process development and production.
Description: