Tools & Metrics

Process Mass Intensity is a common metric used in industry to measure the overall amount (or mass) of materials used to create a given amount (mass) of product. This calculator builds on the original Process Mass Intensity (PMI) calculator to accommodate convergent synthesis. Developed by the ACS Green Chemistry Institute Pharmaceutical Roundtable, the Convergent PMI Calculator uses the same calculations but allows multiple branches for single-step or convergent synthesis.

The DOZN™ tool is a quantitative, industry-first tool that uses the 12 principles of green chemistry for comparing the relative greenness of similar chemicals, synthetic routes, and chemical processes.  We distill these 12 Principles of Green Chemistry into three major categories: improving resource use, more efficient use of energy, and minimizing human and environmental hazards.

ECOTOX is a comprehensive Knowledgebase providing single chemical environmental toxicity data on aquatic and terrestrial species.

Enhesa Chemical Assess provides a comprehensive evaluation of chemicals based on 24 human health and environmental hazard endpoints, covering concerns such as carcinogenicity, reproductive toxicity, endocrine disruption, neurotoxicity, persistence, bioaccumulation, and aquatic toxicity. With rapid screening of over 300,000 substances, the platform enables users to quickly identify potential hazards and make informed choices.

Enhesa Chemical Research with ToxPlanet streamlines chemical research by providing a single, searchable database of scientific, toxicological, and hazard information. With access to over 12 million documents from more than 1,300 databases, users can efficiently find the data they need without the risk of overlooking critical details. The platform enhances research efficiency with features like Projects, allowing users to organize and refer back to their work, and Alerts, which provide updates on any changes in relevant information.

The EPI (Estimation Programs Interface) Suite™ is a suite of Windows-based programs developed by the EPA in collaboration with Syracuse Research Corp. (SRC). It provides estimations for a variety of physical, chemical, and environmental fate properties using a unified input format. The suite includes the following estimation programs:

This tool is a slightly different approach to accounting for Process Mass Intensity (PMI) by focusing on waste. A joint effort by the IQ Consortium, ACS GCI Pharmaceutical Roundtable, and academic leaders, this Green Chemistry Innovation Scorecard web calculator illustrates how green chemistry and engineering innovation can reduce waste mass during bulk active pharmaceutical manufacture. The calculator uses a statistical analysis of 64 bulk active pharmaceutical manufacturing processes encompassing 703 steps across 12 companies to provide a relative process greenness score.