Tools & Metrics

The Process Chemicals Data Collection (PCDC) Tool is a free and publicly available standardized reporting tool that improves the task of collecting and managing process chemicals data. Specifically, the PCDC Tool: 

Decreasing the overall quantity of materials used to manufacture a final product is a significant challenge for pharmaceutical companies. Because of the large amount of solvent used in typical manufacturing processes, decreasing materials used saves companies money (less purchased and less energy used in workup and isolation). The Process Mass Intensity (PMI) metric was developed as a way to benchmark and quantify improvements towards greener manufacturing processes.

The PMI-LCA Tool is a high-level estimator of Process Mass Intensity (PMI) and environmental life cycle information that can be customized to fit a wide variety of linear and convergent processes for synthesis of small molecule active pharmaceutical ingredients (APIs). An ecoinvent dataset is utilized as the source of the life cycle impact assessment (LCIA) data.

PMI-LCA Tool Quick-Start Guide

The Process Mass Intensity (PMI) Prediction Calculator was created by the ACS GCI Pharmaceutical Roundtable member companies, with leadership from Bristol-Myers Squibb, to predict a range of probable process efficiencies of proposed synthetic routes at various phases of drug development. The tool uses historical PMI data from multiple pharmaceutical companies and predictive analytics (Monte Carlo simulations) to estimate the probable PMI ranges.

Looking for safer cleaning and other products? Use the link below to find products that meet the Safer Choice Standard.

What does the Safer Choice label mean?

Participation in the Safer Choice program is voluntary. Companies who make products carrying the Safer Choice label have invested heavily in research and reformulation to ensure that their products meet the Safer Choice Standard. These companies are leaders in safer products and sustainability.

The Qualitative Exposure Assessment (QEA) tool helps facilities fill in information where workplace chemical exposure data is not available. It identifies potential risk of worker exposure to harmful process chemicals within a facility.

The QEA:

The rapid communication explores how to collect mass balance data (reagent amounts, products, waste) to generate metrics to evaluate material circularity and efficiency for chemical transformations. It explores the relationships between three simple metrics (process mass intensity, e-factor, and recycled content) to explore transformations holistically. There is a short case study exploring how these are applied to evaluate and compare different processes. 

The reagent guides purpose is to encourage chemists to choose a ‘greener’ choice of reaction conditions. The guides aim to achieve this by providing transparency through the use of Venn diagrams in addition to improving understanding by discussion and up to date references.

In line with the green chemistry roundtables core values, these guides aim to assist chemists in making informed decisions when picking the most sustainable reagent for any transformation at hand.

The game was designed to introduce students to safer chemical design concepts that are focused on the manipulation of molecule parameters in order to minimize the undesired biological and environmental interactions of a hypothetical commercial chemical. The game scenarios model the decision making process used by professionals to design a new chemical. Critically, the computer game simulates the real-world constraints that may affect chemical product development as the student designs a novel product.